Guard Up returns in Monster Hunter Wilds as a three-level skill that allows you to block otherwise unblockable attacks, though you'll still take chip damage. Higher skill levels reduce the amount of damage taken from these special attacks. For pins and grabs, Guard Up 1 is sufficient since these moves don't deal direct damage, but against endgame monsters, you should always run Guard Up 3 when blocking these attacks, as the chip damage at levels 1 and 2 can still be lethal.

With the introduction of the new Charged Counter move, Guard Up has become less essential for many situations. Any Guard Up attack can be completely avoided using the invincibility frames from a successful Charged Counter. If you're confident with the timing and can read monster attacks well, you can often rely on Charged Counter instead of investing skill points into Guard Up.

However, understanding which attacks require Guard Up or are truly unblockable remains important for defensive play. Below is a comprehensive list of all attacks that need Guard Up to block, as well as those that cannot be blocked even with the skill active.